• Pavlina Teneva Trakia University –Medical College, Stara Zagora
  • Ivelina Dobreva Trakia University – Medical College, Stara Zagora, Republic of Bulgaria
  • Katya Mollova Trakia University - Medical College, Stara Zagora, Republic of Bulgaria



Sars-Cov-2, LDH, D-dimer, Thrombocytes


СОVID-19 is an infеction caused by the new cоrоnavirus Sаrs-Cov-2. For thе specific treatment of patients, it is impоrtant to detеrmine thе sеverity of the disease with thе help of biomarkers when they are hospitalized. Many of them rеveal a range of chаnges in patients with COVID-19. Among the mоst commonly оbserved changes are decreased thrombocytes count, increased D-dimer and LDН values. The aim of the present study is to present the changes in Thrombocytes (Thr), Lactatedehydrogenase (LDH) and D-Dimer values in hospitalized patients with Sars-Cov-2 and the relationship between them. For our research, we took the values from the clinical laboratory results of 106 hospitalized patients for the treatment of Covid-19 in the “St. Ivan Rilski” town of Zagora. Patients were divided into two subgroups depending on the period of their hospitalization. In both groups, the laboratory values of LDH, Thre, D-Dimer on the first day of admission to the hospital are presented. In the two groups of patients studied by us, we found a positive correlation between thrombocytes values and LDH values at admission: r=0.234, p<0.05. A greater number of patients developed thrombocytopenia during hospitalization in Group II 26.53% (n=13). A number of authors have reported that in COVID-19, LDH correlates with disease severity and can be considered a major predictor of lung injury in these patients. Elevation of LDH was observed in over 96% of patients in both groups. Thrombocyte count monitoring during hospitalization is important in the prognosis of patients with coronavirus disease. Thrombocytopenia, elevation of D-dimer, and the following cоmplications in pаtients with COVID-19 аrе among the most common laboratory findings requiring hospitalization.


Download data is not yet available.


Akdogan, D., Guzel, M., Tosun, D., & Akpinar, O. (2021). Diagnostic and early prognostic value of serum CRP and LDH levels in patients with possible COVID-19 at the first admission. Journal of infection in developing countries , 15 (6), 766–772.

Durmus Kocak, N., Oruc, O., Boga, S., Acar, C., Kavas, M., Aydogan Eroglu, S., Gundogus, B., Sogukpinar, O., Bekir, S., Oztin Guven, AA, Akbay, MO, Arinc, S., Duman, D., Takir, HB, Yaman, F., Ozbaki, F., Sonkaya, E., Bulbul, EU, Anil Tokyay, D., Dagyildizi, L., … Torun, T. (2022). Use of Radiology, D-Dimer, and Mean Platelet Volume Combination as a Prognostic Marker in Hospitalized Coronavirus Disease-19 Patients. Frontiers in medicine , 8 , 788551.

Esmailian, M., Vakili, Z., Nasr-Esfahani, M., Heydari, F., & Masoumi, B. (2022). D-dimer Levels in Predicting Severity of Infection and Outcome in Patients with COVID-19. Tanaffos , 21 (4), 419–433.

Ferrari, D., Motta, A., Strollo, M., Banfi, G., & Locatelli, M. (2020). Routine blood tests as a potential diagnostic tool for COVID-19. Clinical chemistry and laboratory medicine , 58 (7), 1095–1099.

Han, H., Yang, L., Liu, R., Liu, F., Wu, KL, Li, J., Liu, XH, & Zhu, CL (2020). Prominent changes in blood coagulation of patients with SARS-CoV-2 infection. Clinical chemistry and laboratory medicine , 58 (7), 1116–1120. .

Han, Y., Zhang, H., Mu, S., Wei, W., Jin, C., Tong, C., Song, Z., Zha, Y., Xue, Y., & Gu, G. (2020). Lactate dehydrogenase, an independent risk factor of severe COVID-19 patients: a retrospective and observational study. Aging , 12 (12), 11245–11258.

Keykavousi K, Nourbakhsh F, Abdollahpour N, Fazeli F, Sedaghat A, Soheili V, Sahebkar A. A Review of Routine Laboratory Biomarkers for the Detection of Severe COVID-19 Disease. Int J Anal Chem. 2022 Oct 11;2022:9006487. doi: 10.1155/2022/9006487. PMID: 36267156; PMCID: PMC9578918

Kermali, M., Khalsa, RK, Pillai, K., Ismail, Z., & Harky, A. (2020). The role of biomarkers in diagnosis of COVID-19 - A systematic review. Life sciences , 254 , 117788.

Lippi, G., & Favaloro, EJ (2020). D-dimer is Associated with Severity of Coronavirus Disease 2019: A Pooled Analysis. Thrombosis and haemostasis , 120 (5), 876–878.

Lippi, G., & Plebani, M. (2020). Laboratory abnormalities in patients with COVID-2019 infection. Clinical chemistry and laboratory medicine , 58 (7), 1131–1134.

Liu, Y., Sun, W., Guo, Y., Chen, L., Zhang, L., Zhao, S., Long, D., & Yu, L. (2020). Association between platelet parameters and mortality in coronavirus disease 2019: Retrospective cohort study. Platelets , 31 (4), 490–496.

Mollova, K., Valeva, S., Bekir, N., & Uzunova, A. (2021). PULMONARY REHABILITATION IN POST - COVID SYNDROME. KNOWLEDGE - International Journal , 49 (4), 661–666. Retrieved from

Naymagon, L., Zubizarreta, N., Feld, J., van Gerwen, M., Alsen, M., Thibaud, S., Kessler, A., Venugopal, S., Makki, I., Qin, Q. , Dharmapuri, S., Jun, T., Bhalla, S., Berwick, S., Christian, K., Mascarenhas, J., Dembitzer, F., Moshier, E., & Tremblay, D. (2020). Admission D-dimer levels, D-dimer trends, and outcomes in COVID-19. Thrombosis research , 196 , 99–105.

Poggiali, E., Zaino, D., Immovilli, P., Rovero, L., Losi, G., Dacrema, A., Nuccetelli, M., Vadacca, GB, Guidetti, D., Vercelli, A., Magnacavallo , A., Bernardini, S., & Terracciano, C. (2020). Lactate dehydrogenase and C-reactive protein as predictors of respiratory failure in CoVID-19 patients. Clinica chimica acta; international journal of clinical chemistry , 509 , 135–138.

Rohlfing, AK, Rath, D., Geisler, T., & Gawaz, M. (2021). Platelets and COVID-19. Haemostaseologie , 41 (5), 379–385.


Thachil J. (2020). What do monitoring platelet counts in COVID-19 teach us?. Journal of thrombosis and haemostasis: JTH , 18 (8), 2071–2072.

Tripodi A. D-dimer testing in laboratory practice. Clin Chem. 2011 Sep;57(9):1256-1262. doi: 10.1373/clinchem.2011.166249. Epub 2011 Jun 30. PMID: 21719689

Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Wang, B., Xiang, H., Cheng, Z., Xiong, Y., Zhao, Y., Li, Y., Wang, X., & Peng, Z. (2020). Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA , 323 (11), 1061–1069.

Wool, GD, & Miller, JL (2021). The Impact of COVID-19 Disease on Platelets and Coagulation. Pathobiology: journal of immunopathology, molecular and cellular biology , 88 (1), 15–27.

Wu, C., Chen, X., Cai, Y., Xia, J., Zhou, X., Xu, S., Huang, H., Zhang, L., Zhou, X., Du, C., Zhang, Y., Song, J., Wang, S., Chao, Y., Yang, Z., Xu, J., Zhou, X., Chen, D., Xiong, W., Xu, L., … Song, Y. (2020). Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China. JAMA internal medicine , 180 (7), 934–943.

Yang, X., Yang, Q., Wang, Y., Wu, Y., Xu, J., Yu, Y., & Shang, Y. (2020). Thrombocytopenia and its association with mortality in patients with COVID-19. Journal of thrombosis and haemostasis: JTH , 18 (6), 1469–1472.

Zhou, F., Yu, T., Du, R., Fan, G., Liu, Y., Liu, Z., Xiang, J., Wang, Y., Song, B., Gu, X., Guan, L., Wei, Y., Li, H., Wu, X., Xu, J., Tu, S., Zhang, Y., Chen, H., & Cao, B. (2020). Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet (London, England) , 395 (10229), 1054–1062.




How to Cite

Teneva, P., Dobreva, I., & Mollova , K. (2023). CONNECTION BETWEEN THROMBOCYTES VALUES AND ELEVATED D-DIMER AND LDH LEVELS IN PATIENTS WITH Sars-Cov-2. MEDIS – International Journal of Medical Sciences and Research, 2(4), 17–22.