TRANSDERMAL APPLICATION OF VITAMIN D AND ITS EFFECTS ON PSORIASIS

Lana Lekić; Bojan Pavlović

doi:10.35120/medisij030107l

Authors

Lana Lekić Faculty of Health Studies, University of Sarajevo,Sarajevo, Bosnia and Herzegovina
Bojan Pavlović MPT, Faculty of Sport and Physical Education Sarajevo, University of East Sarajevo,Sarajevo, Bosnia and Herzegovina

DOI:

https://doi.org/10.35120/medisij030107l

Keywords:

vitamin D, psoriasis, participants, scalp, joints, lumbal region, hands

Abstract

Psoriasis represents a disorder of skin hypoproliferation, where vitamin D is frequently utilized in its treatment. Ultraviolet (UV) radiation stimulates the synthesis of vitamin D3 (cholecalciferol) in the epidermis. This compound undergoes further conversion into active metabolites, specifically 25-hydroxycholecalciferol and 1,25-hydroxycholecalciferol, which play crucial roles in skin health. However, in conditions like psoriasis, disruptions in skin functioning impede the cutaneous production of vitamin D, initiating a detrimental cycle. This disruption leads to a gradual reduction in vitamin D levels throughout the body, consequently destabilizing skin homeostasis. Topical application of vitamin D enables a substantial reduction in psoriasis on target areas of the body such as the scalp, joints, hands and lumbar region. The research records reductions of 100%, 80%, and 50% in the mentioned regions.

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