BLOOD DONATION IN DONORS WITH ARTERIAL HYPERTENSION: CURRENT ELIGIBILITY CRITERIA AND CHALLENGES
DOI:
https://doi.org/10.35120/medisij0503147bAbstract
Blood donation occupies a central place in modern transfusion medicine and is essential for ensuring timely and safe transfusion therapy. The effective functioning of transfusion systems depends directly on maintaining a stable pool of voluntary and regular blood donors, which requires optimization of donor selection while strictly adhering to medical and ethical principles for protecting donor health.
Over recent decades, chronic non-communicable diseases have tended to occur at younger ages worldwide, changing the health profile of potential donors and creating new challenges for transfusion medicine. Conditions traditionally associated with older age are increasingly being seen in younger people, resulting in a growing proportion of individuals with chronic conditions who are willing to participate in blood donation programs. In this context, arterial hypertension has become one of the most common chronic conditions and affects a substantial proportion of working-age adults, including potential blood donors. Its increasing prevalence poses challenges for transfusion practice, particularly with regard to reconsidering traditional eligibility criteria, individual risk assessment, and ensuring donor safety during and after donation.
Historically, arterial hypertension was often regarded as a relative or absolute contraindication to blood donation because of concerns about adverse hemodynamic reactions. Current scientific evidence and international guidelines support a more differentiated approach in which the degree of blood pressure control, the stability of antihypertensive therapy, and the absence of clinically significant complications are the key considerations. Accordingly, the presence of arterial hypertension alone is increasingly recognized as not constituting an automatic contraindication to blood donation.
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References
AABB, America’s Blood Centers, & American Red Cross. (2022). Joint comments to the U.S. Food and Drug Administration on blood pressure and pulse donor eligibility requirements.
Bundesärztekammer. (2023). Richtlinie zur Gewinnung von Blut und Blutbestandteilen und zur Anwendung von Blutprodukten (Richtlinie Hämotherapie): Gesamtnovelle 2023. Bundesärztekammer.
Bundeszentrale für gesundheitliche Aufklärung. (2023). Blutspende – Voraussetzungen und Ausschlusskriterien. Bundeszentrale für gesundheitliche Aufklärung.
Canadian Blood Services. (n.d.). Eligibility: Medical conditions and treatments. Canadian Blood Services.
Canadian Blood Services. (2022). Donor eligibility and wellness guidelines. Canadian Blood Services.
Clement, M., Shehu, E., & Chandler, T. (2021). The impact of temporary deferrals on future blood donation behavior across the donor life cycle. Transfusion, 61(6), 1799–1808. https://doi.org/10.1111/trf.16387
Debecho, D. A., & Hailu, A. (2019). Assessment of blood donation safety by people diagnosed with diabetes, hypertension, malaria and cancer. Journal of Advances in Medicine and Medical Research, 29(10), 1–8. https://doi.org/10.9734/JAMMR/2019/v29i1030136
Eder, A. F., Hillyer, C. D., Dy, B. A., Notari, E. P., & Benjamin, R. J. (2009). Adverse reactions to allogeneic whole blood donation by 16- and 17-year-olds. JAMA, 301(22), 2279–2286.
European Directorate for the Quality of Medicines & HealthCare. (2025). Guide to the preparation, use and quality assurance of blood components (22nd ed.). Council of Europe.
European Directorate for the Quality of Medicines & HealthCare. (2023). Guide to the preparation, use and quality assurance of blood components (21st ed.). Council of Europe.
Goldman, M., Osmond, L., Yi, Q.-L., Cameron-Choi, K., & O’Brien, S. F. (2013). Frequency and risk factors for donor reactions in an anonymous blood donor survey. Transfusion, 53(9), 1979–1984. https://doi.org/10.1111/trf.12011
Housekeeper, J. R., Adams, S. A., Patel, R. R., & Shaz, B. H. (2020). Large number of blood donors have hypertension based on the updated 2017 ACC/AHA hypertension guidelines. Annals of Blood, 5, Article 21. https://doi.org/10.21037/aob.2020.03.02
Irish Blood Transfusion Service. (n.d.). Blood pressure: High or low. Irish Blood Transfusion Service.
Irish Blood Transfusion Service. (2023). Donor eligibility guidelines. Irish Blood Transfusion Service.
Johnsen, J. M., Ullum, H., Petersen, M. S., et al. (2023). Risk factors for vasovagal reactions in blood donors: A large cohort study. Transfusion, 63(1), 45–54. https://doi.org/10.1111/trf.17223
Johnsen, K. M. N., Magnussen, K., Erstad, C., Bhatti, S. N., & Nissen-Meyer, L. S. H. (2023). Safe blood donation from donors using antihypertensive medication: A multi-center retrospective quality study from South-East Norway. Journal of Blood Medicine, 14, 337–343. https://doi.org/10.2147/JBM.S390609
Joint United Kingdom Blood Transfusion and Tissue Transplantation Services Professional Advisory Committee. (2022). Donor selection guidelines. UK Blood Transfusion and Tissue Transplantation Services.
Joint Professional Advisory Committee. (2022). Guidelines for the Blood Transfusion Services in the United Kingdom (8th ed.). Joint Professional Advisory Committee.
Joint Professional Advisory Committee. (2026). Whole blood and component donor selection guidelines (Edition 203, Release 79). UK Blood Transfusion and Tissue Transplantation Services.
Lamba, R., Kaur, P., Sharma, S., et al. (2023). Causes of donor deferral and their impact on donor return: A systematic review. Transfusion Medicine Reviews, 37(1), 15–24. https://doi.org/10.1016/j.tmrv.2022.10.002
Lamba, D. S., Sachdev, S., Hans, R., Krishan Dhawan, H., Sharma, R. R., & Marwaha, N. (2023). Review of blood donor deferral with emphasis on donor and patient safety. Transfusion Clinique et Biologique, 30(1), 56–62. https://doi.org/10.1016/j.tracli.2022.07.002
Maghsudlu, M., Teimourpour, A., Amini-Kafiabad, S., Nazemi, A. M., O’Brien, S. F., & Sarem, F. (2024). The return rate of deferred blood donors in Iran. Transfusion Clinique et Biologique, 31(3), 135–140. https://doi.org/10.1016/j.tracli.2024.04.002
Makowicz, D., Dziubaszewska, R., Lisowicz, K., & Makowicz, N. (2022). Impact of regular blood donation on the human body: Donors’ perspective. Journal of Transfusion Medicine, 15(2), 133–140. https://doi.org/10.5603/JTM.2022.0011
McEvoy, J. W., McCarthy, C. P., Bruno, R. M., Elliott, W. J., Hayward, C., Laurent, S., et al. (2024). 2024 ESC guidelines for the management of elevated blood pressure and hypertension. European Heart Journal, 45(38), 3912–4018. https://doi.org/10.1093/eurheartj/ehae178
Ministero della Salute. (2023). Chi può donare il sangue. Ministero della Salute.
Ministry of Health of the Republic of Bulgaria. (2006). Ordinance No. 9 of 25 April 2006 approving the medical standard “Transfusion Hematology.” State Gazette, No. 41 of 19 May 2006, as subsequently amended and supplemented. [in Bulgarian].
New Zealand Blood Service. (2021). Blood donor eligibility criteria. New Zealand Blood Service.
Newman, B. H. (2013a). Blood donor complications after whole-blood donation. Current Opinion in Hematology, 20(6), 533–537. https://doi.org/10.1097/MOH.0b013e328365a90b
Newman, B. H. (2013b). Donor suitability and hypertension. Transfusion, 53(6), 1149–1153. https://doi.org/10.1111/trf.12008
Nissen-Meyer, L. S. H., & Seghatchian, J. (2019). Donor health assessment—When is blood donation safe? Transfusion and Apheresis Science, 58(1), 113–116. https://doi.org/10.1016/j.transci.2018.12.016
Penjišević, A., & Sančanin, B. (2023). Key factors for safe and rational security of blood and blood components. MEDIS – International Journal of Medical Sciences and Research, 2(3), 19-24. https://doi.org/10.35120/medisij020319p
République Française. (2016). Arrêté du 5 avril 2016 fixant les critères de sélection des donneurs de sang: Annexe II (version updated September 2, 2025). Légifrance.
Ringdal, K. G., Lappegård, J., Wiersum-Osselton, J., et al. (2022). Blood donor selection and deferral in Europe: Past, present and future. Vox Sanguinis, 117(6), 729–738.
Ringdal, K. G., Kjaergaard, J., Ullum, H., et al. (2022). Blood pressure and adverse donor reactions: A population-based cohort study. Transfusion, 62(4), 789–798. https://doi.org/10.1111/trf.16851
Stainsby, D., Brunskill, S., Chapman, C. E., Dorée, C., & Stanworth, S. (2010). Safety of blood donation from individuals with treated hypertension or non-insulin dependent type 2 diabetes: A systematic review. Vox Sanguinis, 98(3), 431–440. https://doi.org/10.1111/j.1423-0410.2009.01275.x
Thibeault, C., Lewin, A., Rabusseau, I., & Germain, M. (2025). Deferring blood donors with out-of-range blood pressure: Does it decrease the risk of adverse reactions? Transfusion, 65(6), 1083–1091. https://doi.org/10.1111/trf.18264
U.S. Food and Drug Administration. (2026). Code of Federal Regulations, Title 21, Part 630: Requirements for blood and blood components. U.S. Government Publishing Office.
Wang, H.-H., Chen, P.-M., Lin, C.-L., Jau, R.-C., Hsiao, S.-M., & Ko, J.-L. (2019). Joint effects of risk factors on adverse events associated with adult blood donations. Medicine, 98(44), e17758. https://doi.org/10.1097/MD.0000000000017758
Williams, B., Mancia, G., Spiering, W., Agabiti Rosei, E., Azizi, M., Burnier, M., et al. (2018). 2018 ESC/ESH guidelines for the management of arterial hypertension. European Heart Journal, 39(33), 3021–3104. https://doi.org/10.1093/eurheartj/ehy339
World Health Organization. (2012). Blood donor selection: Guidelines on assessing donor suitability for blood donation. World Health Organization.
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