IMPACT OF INOSITOL SUPPLEMENTATION ON ENDOCRINE FUNCTION, MENTAL HEALTH AND CARDIOVASCULAR RISK FACTORS: A CLINICAL STUDY

Hajrudin Spahović; Lana Lekić

doi:10.35120/medisij0502083s

Authors

Hajrudin Spahović Urology Clinic, University Clinical Center Sarajevo Author
Lana Lekić Faculty of Health Studies, University of Sarajevo,Sarajevo, Bosnia and Herzegovina Author

DOI:

https://doi.org/10.35120/medisij0502083s

Keywords:

Inositol, endocrine parameters, cardiovascular parameters, depression, mental health

Abstract

This study investigates the effects of 30 mg inositol supplementation on endocrine, mental health, and cardiovascular parameters in 20 participants. Pre- and post-treatment measurements were taken to evaluate changes in insulin, androgen levels, glucose, blood pressure, lipid profiles (LDL, HDL, total cholesterol, triglycerides), depression, anxiety, general mental clarity, energy, and fatigue. Results showed significant improvements in endocrine and cardiovascular parameters, including a reduction in insulin levels (from 15 µU/mL to 11 µU/mL, p=0.05), androgen levels (from 50 ng/dL to 45 ng/dL, p=0.04), and blood pressure (from 140/100 mmHg to 115/75 mmHg, p=0.05). Lipid profiles also improved, with LDL decreasing from 135 mg/dL to 120 mg/dL (p=0.02), HDL increasing from 45 mg/dL to 55 mg/dL (p=0.03), and triglycerides decreasing from 150 mg/dL to 130 mg/dL (p=0.04). Mental health assessments revealed significant reductions in depression (PHQ-9 score from 10 to 5, p=0.02) and anxiety (GAD-7 score from 8 to 4, p=0.01), along with an improvement in general mental clarity (from 60 to 75, p=0.04). Energy levels showed a significant increase (from 60 to 75, p=0.05), while fatigue was slightly reduced, but not significantly (from 70 to 60, p=0.07). These findings suggest that inositol supplementation may offer substantial benefits in improving metabolic, cardiovascular, and mental health outcomes. Further studies with larger sample sizes and longer durations are needed to confirm these results and explore the underlying mechanisms of action.

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